Finsk musik är inte bara tango. Nu kan du få en glimt av vad som händer med ditt DNA när du lyssnar/spelar musik.
Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory
motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the
brains of professional musicians and non-musicians differ structurally and functionally and that musical
training enhances cognition. However, the molecules and molecular mechanisms involved in music
performance remain largely unexplored. Here, we investigated the effect of music performance on the
genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional
responses after a 2-hr concert performance and after a ‘music-free’ control session. The up-regulated genes
were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity, and
neurocognitive functions including learning and memory. Particularly, candidate genes such asSNCA,FOS
andDUSP1that are involved in song perception and production in songbirds, were identified, suggesting an
evolutionary conservation in biological processes related to sound perception/production. Additionally,
modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism, and
several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the
biological pathways that are otherwise essential for the proper maintenance of neuronal function and
survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms
underlying music performance.
http://www.nature.com/srep/2015/150325/ ... p09506.pdf
JM
